OpenScience
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The open-source AI workbench for scientific research

One workspace for literature, code, experiments, compute, and results. Free models included, or bring Claude, GPT, Gemini and any other provider.

T4 lysozyme stability scan
18.4K2%
Which T4 lysozyme point mutants are predicted to be stabilizing? Compare against ProTherm measurements and plot ΔΔG predicted vs. measured.
Thought 3s
ProTherm has measured ΔΔG for 2LZM point mutants; that is the comparison set. Score the same 26 mutants on the structure, then plot predicted against measured.
Loaded skill: research-lookup
Searched 2 sources, read 1 file
Cross-check ProTherm entriesCompleted42sExplore agent
Ran python ddg_scan.py --pdb structures/2LZM.pdb
Generated · 1
ddg_vs_protherm.pngPNG · 1200 × 900
Describe the research task you want to work through…
ToolsClaude Opus 5High

What is OpenScience?

OpenScience is an open-source agent that reads papers, writes code, and runs experiments with you.

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    Model agnosticFree models included, or your own keys for any provider
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    Scientific databasesUniProt, PDB, ChEMBL, PubChem, arXiv, and 37 more, as tools
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    Bundled skills371 skills across biology, chemistry, physics, ML, and writing, with a curated research core
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    ChatGPT Plus/ProSign in with OpenAI to use the subscription you already have
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    Manages computeBuilds environments and scales on demand: your laptop, cluster, or GPUs
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    Multi-sessionRun several agents in parallel on the same project
Read docs

The state-of-the-art AI co-scientist

OpenScience leads every scientific benchmark we have run: Terminal-Bench Science, Terminal-Bench 4.0 (science), BiomniBench-DA, and OpenScience Bench, which measures end-to-end research. See the benchmark report.

50%70%90%LifePhys.EarthMathEng.solved, by domainOpenScience
Fig 1.75.7%Terminal-Bench Science
solved, best entryOpenScience71.4%Claude Code60%Codex45.7%Grok Build30%
Fig 2.71.4%Terminal-Bench 4.0 (science)
2550751001255050 tasks, by scorescoreOpenScience 82.2AIPOCH 81.04
Fig 3.82.2BiomniBench-DA
solved, pass@3OpenScience47.3%Claude Science40.6%K-Dense40.3%Codex38.1%Grok Build12.2%
Fig 4.47.3%OpenScience Bench (pass@3)

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